Evidence map›Paper›PMID 41133886›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Arid1a Deficiency Drives Aristolochic Acid-Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair.

Lan Wang, Shi-Hao Bai, Shu-Jin Song, Xiao-Li Zhang, Xue-Ying Shang, Zhao-Ning Lu, Xiao-Fang Cui, Xin-Le Zhu, Ze-Guang Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lan WangKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Shi-Hao BaiKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Shu-Jin SongKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xiao-Li ZhangKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xue-Ying ShangKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhao-Ning LuKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xiao-Fang CuiKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xin-Le ZhuKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Ze-Guang HanKey Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0000-0002-1018-1752

Funding

111 project B17029Fundamental Research Funds for the Central Universities KLSB2024KF-01National Key Research and Development Program of China 2022YFA1302700National Natural Science Foundation of China 82272969National Natural Science Foundation of China 82441040National Natural Science Foundation of China 82472880Natural Science Foundation of Shanghai 21JC1403200
6 · The paper itself

Abstract

ARID1A, which encodes an important subunit of SWI/SNF complex, is frequently mutated in non-malignant tissues and tumors. However, how ARID1A loss enables environmental carcinogens to initiate tumorigenesis remains unknown. Here, liver-specific Arid1a-deficient (Arid1a

Indexed as

Aristolochic Acidsbeta CateninCarcinogenesisDNA-Binding ProteinsDNA RepairLiver NeoplasmsTranscription FactorsAnimalsExcision RepairLiverMiceMice, KnockoutMutationArid1a protein, mousearistolochic acid IAristolochic Acidsbeta CateninCTNNB1 protein, mouseDNA-Binding ProteinsTranscription FactorsARID1Aaristolochic acidliver cancerNqo1nucleotide excision repairSWI/SNF complex

Identifiers

PMID41133886
PMCPMC12806303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.