ArticleThoracic research and practice2025
Effect of Ambient Air Pollutants on Acute changes in Pulmonary Variables and Inflammatory Markers in Healthy Adults: A Pilot Study.
Article in Thoracic research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
objectiveAir pollution is associated with adverse health effects, particularly on respiratory and cardiovascular systems. Smog, prevalent in Northern India, contains particulate matter (PM10, PM2.5) and gaseous pollutants that can impair pulmonary function. Ambient air pollution can be quantified by the air quality index (AQI). Understanding the acute effects of air quality on respiratory physiology and inflammation is essential. MATERIAL AND
methodsA pilot prospective longitudinal observational study evaluated healthy volunteers during high (HAQI, AQI >350) and low pollution (LAQI, AQI <150) phases. Spirometry and impulse oscillometry (IOS) assessed lung function; and biomarkers (interleukin-6, tumor necrosis factor alpha) were measured from exhaled breath condensate (EBC) and serum. Paired t-tests or Wilcoxon signed-rank tests were used for analysis.
resultsA total of 21 participants (mean age 25.4±7.4 years, female 33.3%, body mass index 23.9±3.5 kg/m
conclusionAcute air pollution exposure impairs lung function and increases airway resistance in healthy adults. These findings underscore the need for larger longitudinal studies to clarify the mechanisms linking acute air pollution exposure to chronic health outcomes.
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