Evidence map›Paper›PMID 41133714›Full record

ArticleEpigenomes2025

A Pilot Epigenome-Wide Study of Posttraumatic Growth: Identifying Novel Candidates for Future Research.

Mackenzie Rubens, Paul Ruiz Pinto, Anita Sathyanarayanan, Olivia Miller, Amy B Mullens, Dagmar Bruenig, Patricia Obst, Jane Shakespeare-Finch, Divya Mehta

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In one paragraph

Article in Epigenomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mackenzie RubensCentre for Genomics and Personalised Health, Queensland University of Technology (QUT), Kelvin Grove, QLD 4059, Australia.ORCID 0000-0002-5642-2654
Paul Ruiz PintoCentre for Genomics and Personalised Health, Queensland University of Technology (QUT), Kelvin Grove, QLD 4059, Australia.
Anita SathyanarayananCentre for Genomics and Personalised Health, Queensland University of Technology (QUT), Kelvin Grove, QLD 4059, Australia.ORCID 0000-0001-8385-5618
Olivia MillerSchool of Psychology and Counselling, Queensland University of Technology (QUT), Kelvin Grove, QLD 4059, Australia.ORCID 0000-0001-5727-4254
Amy B MullensSchool of Psychology and Wellbeing, University of Southern Queensland (USQ), Toowoomba, QLD 4350, Australia.ORCID 0000-0002-0939-9842
Dagmar BruenigCentre for Genomics and Personalised Health, Queensland University of Technology (QUT), Kelvin Grove, QLD 4059, Australia.ORCID 0000-0002-3760-7098
Patricia ObstSchool of Psychology and Counselling, Queensland University of Technology (QUT), Kelvin Grove, QLD 4059, Australia.ORCID 0000-0001-7977-7821
Jane Shakespeare-FinchSchool of Psychology and Counselling, Queensland University of Technology (QUT), Kelvin Grove, QLD 4059, Australia.
Divya MehtaCentre for Genomics and Personalised Health, Queensland University of Technology (QUT), Kelvin Grove, QLD 4059, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPosttraumatic growth (PTG) refers to positive psychological change following trauma. While its psychological aspects are well-documented, the biological mechanisms remain unclear. Epigenetic changes, such as DNA methylation (DNAm), may offer insight into PTG's neurobiological basis.

aimsThis study aimed to identify epigenetic markers associated with PTG using an epigenome-wide association study (EWAS), the first of its kind in a trauma-exposed population.

methodsA longitudinal EWAS design was used to assess DNAm before and after trauma exposure in first-year paramedicine students (n = 39). Genome-wide methylation data were analyzed for associations with PTG, applying epigenome-wide and gene-wise statistical thresholds. Pathway enrichment analysis was also conducted.

resultsThe study identified two CpGs (cg09559117 and cg05351447) within the PCDHA1/PCDHA2 and PDZD genes significantly associated with PTG at the epigenome-wide threshold (

conclusionsThese results identify genes for PTG, improving our understanding of the neurobiological underpinnings of PTG.

Indexed as

DNA methylationEWASposttraumatic growthposttraumatic stress disorderstress

Identifiers

PMID41133714
PMCPMC12551033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.