ArticleNeuroSci2025
STING Signaling Deficiency Exacerbates Demyelination and Immune Infiltration in Focal EAE Lesions.
Marlene T Mørch, Line S Reinert, Anouk Benmamar-Badel, Magdalena Dubik, Mark Burton, Mads Thomassen, Torben Kruse, Nasrin Asgari, Søren R Paludan, Trevor Owens and 1 more
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In one paragraphArticle in NeuroSci, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Marlene T MørchDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
Line S ReinertDepartment of Biomedicine, University of Aarhus, Høegh-Guldbergs Gade 10, 8000 Aarhus C, Denmark.ORCID 0000-0002-8317-0886 Anouk Benmamar-BadelDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
Magdalena DubikDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.ORCID 0000-0002-4521-0410 Mark BurtonDepartment of Clinical Genetics, Odense University Hospital, J.B. Winslows Vej 4, Entrance 24, 5000 Odense, Denmark.ORCID 0000-0002-3782-5933 Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, J.B. Winslows Vej 4, Entrance 24, 5000 Odense, Denmark.
Torben KruseDepartment of Clinical Genetics, Odense University Hospital, J.B. Winslows Vej 4, Entrance 24, 5000 Odense, Denmark.
Nasrin AsgariDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
Søren R PaludanDepartment of Biomedicine, University of Aarhus, Høegh-Guldbergs Gade 10, 8000 Aarhus C, Denmark.
Trevor OwensDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.ORCID 0000-0001-9315-6036 Reza KhorooshiDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.ORCID 0000-0002-6164-4972 Funding
a postdoctoral stipend from Warwara Larsens Fond, and Ph.D. stipends from The University of Southern Denmark Health Sciences FacultyBjarne Jensens FondDagmar Marshalls FondDanish Multiple Sclerosis SocietyFamilien Hede Nielsens FondFonden for lægevidenskabelige fremmeThe Lundbeck Foundation R198-2015-171
6 · The paper itselfAbstract
Stimulator of interferon genes (STING) is a cytosolic DNA sensor that activates type I interferon (IFN) signaling, which plays a key role in neuroinflammation. Although the role of STING in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), remains debated, its involvement in the development of CNS lesions, particularly within localized pathology, modeled here by targeting the corpus callosum, has yet to be explored. Using a focal EAE model, we compared the induction of lesions in wild-type and STING-deficient (STING
Indexed as
EAEfocal brain pathologySTINGtype I IFN
Identifiers
PMID41133642
PMCPMC12551006
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