Evidence map›Paper›PMID 41133527›Full record

ArticlePathophysiology : the official journal of the International Society for Pathophysiology2025

Carbon Monoxide in an Experimental Model of Chronic Pelvic Pain Syndrome: The Effects of CORM-A1 on Pain and Anxiety-Related Behaviors.

Nikola Šutulović, Neriman Ezgin, Nela Puškaš, Emilija Đurić, Željko Grubač, Daniel Škrijelj, Milena Vesković, Dušan Mladenović, Isidora Savić, Djuro Macut and 4 more

Abstract read
In one paragraph

Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nikola ŠutulovićInstitute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0002-9499-3247
Neriman EzginInstitute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0002-7016-2334
Nela PuškašInstitute of Histology and Embryology "Aleksandar Đ. Kostić", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0002-5921-974X
Emilija ĐurićInstitute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.
Željko GrubačInstitute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0002-0812-2438
Daniel ŠkrijeljClinic of Urology, University Clinical Center of Serbia, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0002-5835-4819
Milena VeskovićInstitute of Pathophysiology "Ljubodrag Buba Mihailovic", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0002-7505-5466
Dušan MladenovićInstitute of Pathophysiology "Ljubodrag Buba Mihailovic", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0002-8921-6232
Isidora SavićInstitute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.
Djuro MacutClinic of Endocrinology, Diabetes and Metabolic Disease, University Clinical Centre of Serbia, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0002-6731-8596
Yavuz DodurgaDepartment of Medical Biology, Faculty of Medicine, University of Pamukkale, Denizli 20160, Turkey.
Aleksandra Rašić-MarkovićInstitute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.
Olivera StanojlovićInstitute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.
Dragan HrnčićInstitute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.ORCID 0000-0003-0806-444X

Funding

TUBITAK FA4LinWellcome Trust 200110
6 · The paper itself

Abstract

Current standard treatments for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a urological disorder with anxiety as a major comorbidity, are limited in success rates. Recent findings revealed the anti-inflammatory and neuroprotective effects of CO-releasing molecules (CO-RMs), but there is a gap in the knowledge on its effects in CP/CPPS. Therefore, the objective of our study was to investigate the potential therapeutic effects of CORM-A1 on the scrotal pain threshold and anxiety-related behaviors in experimental model of CP/CPPS. Adult Wistar albino male rats were randomized to Sham (intraprostatic saline) or CP/CPPS (intraprostatic λ-carrageenan) groups (

Indexed as

anxiety-related behaviorcarbon monoxide-realizing moleculesCORM A1painprostatitisrats

Identifiers

PMID41133527
PMCPMC12551041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.