Evidence map›Paper›PMID 41133473›Full record

ReviewCurrent opinion in rheumatology2026

Environmental and occupational contributors to autoimmune, inflammatory, and musculoskeletal rheumatic disease: a review of emerging evidence and clinical implications.

Nicole K Ward, Richard S Panush

Abstract readReview
In one paragraph

Review in Current opinion in rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicole K WardDivision of Rheumatology, Department of Medicine Cedars Sinai Medical Center, Los Angeles, California.
Richard S PanushDivision of Rheumatology, Department of Medicine, Keck Medical School, University of Southern California, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewAutoimmune and inflammatory rheumatic diseases as well as certain musculoskeletal diseases treated by rheumatologists result from a complex interplay between genetic predisposition and environmental factors. RECENT

findingsAccumulating research has examined the possible roles of physical trauma, psychological stress, pollutants, and occupational exposures as triggers or influencers of disease. We review and summarize existing evidence for these contributors for conditions including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, spondyloarthritis, systemic sclerosis, Sjogren's syndrome, vasculitis, myositis and fibromyalgia. We highlight findings from case-control, cohort, and twin studies that associate trauma, chronic stress and environmental exposure with immune dysregulation and increased disease risk. We apply the GRADE framework to assess the strength of evidence and identify key research gaps. Summary tables are included to guide clinical assessment which could also support interdisciplinary communication in medico-legal contexts. SUMMARY: These data have implications for disease etiopathogenesis; management; historical appreciation; public health, policy and safety; and legal considerations.

Indexed as

Autoimmune DiseasesEnvironmental ExposureMusculoskeletal DiseasesOccupational ExposureRheumatic DiseasesHumansautoimmune diseaseenvironment exposuresoccupational riskrheumatologytrauma

Identifiers

PMID41133473
PMCPMC12863618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.