ReviewInternational journal of molecular medicine2025
Periostin: A matricellular protein with a multifaceted role in tumorigenesis (Review).
Review in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exercise therapy-associated changes in Periostin (POSTN) osteoarthritis are linked to Hippo-YAP signaling.Molecular biology reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular matrix (ECM) proteins are key non‑cellular components of the tumor microenvironment and include structural and non‑structural proteins. POSTN belongs to a family of non‑structural matrix cell proteins first identified in bone and periodontal ligaments. POSTN exerts its multiple effects mainly through specific binding to other ECM proteins, growth factors and cytokines. Physiologically, POSTN is rarely expressed in adult tissues, except in the periosteum and some collagen‑rich connective tissues, such as periodontal ligaments and heart valves, but is highly expressed during inflammation, tissue repair, wound healing and malignant transformation. POSTN carries out an important role in tumor development. The present review summarizes the multiple roles of POSTN in tumorigenesis and development. First, the molecular structure of POSTN and its physiological and pathological expression, especially in known tumors is reviewed. Second, the manner in which POSTN affects tumor cells through relevant cancer hallmarks is discussed. Finally, the molecular mechanisms underlying the promotion of cancer by POSTN from the perspective of the TME is summarized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.