Evidence map›Paper›PMID 41133451›Full record

ArticleOncology reports2026

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells.

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xingdong Hou *Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China.
Yuting Wang *Department of Thoracic Surgery, Binzhou People's Hospital, Binzhou, Shandong 256610, P.R. China.
Yuzhuo ChenDepartment of Clinical Nutrition, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R China.
Peiyan ZhongDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China.
Guangzhi WangDepartment of Thyroid Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R China.
Baicheng LiDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China.
Bowei LuDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China.
Hanyu JiangDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.
Shili NingDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leucine‑rich repeat‑containing protein 59 (LRRC59), a 244‑amino‑acid endoplasmic reticulum membrane protein, is implicated in the tumorigenesis of multiple malignancies. However, its functional significance in colorectal cancer (CRC) remains poorly understood. In the present study, LRRC59 expression in CRC tissues was evaluated using immunohistochemistry and western blotting. Colony formation, Cell Counting Kit‑8, wound healing and Transwell assays, in

Indexed as

Colorectal NeoplasmseIF-2 KinaseMembrane ProteinsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansIntracellular Signaling Peptides and ProteinsMaleMiceMiddle AgedEIF2AK3 protein, humaneIF-2 KinaseIntracellular Signaling Peptides and ProteinsMembrane ProteinsRETREG1 protein, humanapoptosiscolorectal cancerendoplasmic reticulum stressleucine‑rich repeat‑containing protein 59PERK pathway

Identifiers

PMID41133451
PMCPMC12576520

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.