Visceral adipose tissue accumulation and risk of organ complications among individuals with type 2 diabetes mellitus: A two-sample Mendelian randomization study.

Xingji Lian, Xiaomin Zeng, Bing Zhang, Yan Huang, Xiaohui Peng, Yanhui Wang, Chongzhe Yang, Yuyu Huang

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Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Xingji LianDepartment of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Xiaomin ZengDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Bing ZhangDepartment of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Yan HuangDepartment of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Xiaohui PengDepartment of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Yanhui WangDepartment of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Chongzhe YangDepartment of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Yuyu HuangDepartment of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID 0009-0007-8255-5059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral adiposity is a pivotal pathogenic driver of type 2 diabetes mellitus (T2DM) and its vascular complications. We performed two-sample Mendelian randomization (MR) analyses to examine the causal relationships between visceral adipose tissue (VAT) accumulation and diabetes complications. Single nucleotide polymorphisms (SNPs) specific to VAT accumulation were identified through large-scale genome-wide association studies (GWAS) at genome-wide significance (

Indexed as

AdiposityDiabetes Mellitus, Type 2Intra-Abdominal FatPolymorphism, Single NucleotideGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisPhenotypeRisk AssessmentRisk Factorsdiabetes complicationsmendelian randomizationtype 2 diabetes mellitusvascular complicationsvisceral adipose tissue

Identifiers

PMID41133440

DOI10.1177/14791641251388653

PMCPMC12569360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.