ArticleJournal of the American Chemical Society2025
Stereoselective Photoenzymatic Hydroarylation for the Construction of Quaternary Stereocenters.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Asymmetric Hydroamination Using Oxidative Radical Initiation in Flavin Enzymes.Journal of the American Chemical Society · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Quaternary carbon stereocenters are a crucial component of many bioactive molecules, but they can be challenging to prepare stereoselectively. Olefin hydroarylations are an attractive means for preparing this motif; however, existing methods struggle to set stereocenters on substrates lacking traditional catalyst binding handles. Here, we report a stereoselective photoenzymatic olefin hydroarylation using a repurposed Baeyer-Villiger monooxygenase. Three rounds of iterative site-saturation mutagenesis yielded a photoenzyme capable of preparing valuable tetrahydroquinolines in high yields with excellent enantioselectivity. The engineered variant accepts various arene substituents, highlighting the synthetic utility of this methodology. DFT calculations and control experiments suggest that the protein templates a through-space interaction between the tertiary radical and aromatic group, which attenuates the oxidation potential of the radical, enabling C-C bond formation.
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Registered trials
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