ArticleJournal of multidisciplinary healthcare2025
Clinical Outcomes and Safety of a Triple-Modality Approach Combining Decompression, Vertebral Augmentation, and Radiotherapy for Thoracolumbar Metastatic Tumors With Neurological Involvement.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the clinical efficacy and safety of a triple-modality therapy-decompression, vertebral augmentation, and radiotherapy-in patients with thoracolumbar metastatic tumors accompanied by neurological injury. Methods: A retrospective analysis was performed involving 86 patients who underwent treatment for thoracolumbar metastatic tumors with neurological involvement between January 2017 and December 2022. Participants were categorized into two groups: a control group (n = 45) that received conventional separation surgery combined with pedicle screw fixation, and an intervention group (n = 41) that received the triple-modality therapy. This therapeutic approach comprised (1) decompression through separation surgery, which involved excision of tumor tissue adjacent to the dura mater to establish a protective margin; (2) vertebral augmentation via bone cement injection into the affected vertebrae, along with bone cement-augmented pedicle screw fixation; and (3) stereotactic radiosurgery. Postoperative outcomes, including pain intensity, neurological function, and quality of life, were assessed and compared between groups. Results: The intervention group experienced significantly longer surgical durations but demonstrated reduced intraoperative blood loss compared with the control group ( Conclusion: The decompression-vertebral augmentation-radiotherapy triple-modality therapy demonstrated efficacy in alleviating pain, promoting neurological recovery, and improving quality of life while maintaining spinal stability and a low rate of complications.
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