ArticleFrontiers in endocrinology2025
Association of blood urea nitrogen to serum albumin ratio with arterial stiffness in type 2 diabetes patients: a Chinese cross-sectional study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
Background: Arterial stiffness is an early indicator of atherosclerosis. The blood urea nitrogen to serum albumin ratio(BAR) is associated with poor prognosis in several chronic diseases. However, the relationship between BAR and arterial stiffness in type 2 diabetes mellitus (T2DM) patients has not been extensively studied. This study aimed to examine the relationship between BAR and brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness in patients newly diagnosed with T2DM. Methods: A total of 510 adult patients newly diagnosed with T2DM were enrolled between January 2021 and December 2023. BAR was calculated by blood urea nitrogen/albumin ratio. A baPWV ≥1400 cm/s was defined as arterial stiffness. A linear regression model and logistic regression model were used to assess the relationship between BAR and baPWV after adjusting for potential confounders. Results: The average age of the patients in this study was 45.66 ± 10.18 years, and 78.8% were male. The mean baPWV was 1469.15 ± 295.82 cm/s, and 50.8% of patients exhibited arterial stiffness. The prevalence of arterial stiffness increased significantly across ascending BAR tertiles (T1: 39.3%, T2: 51.7%, T3: 61.4%; Conclusion: BAR levels were independently and positively correlated with baPWV in Chinese patients with newly diagnosed T2DM.
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