ReviewFrontiers in cell and developmental biology2025
Research progress on the role of biomechanical clues in the progression of lung cancer.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A mechanical stimulation-related gene signature predicts prognosis, reflects immune microenvironment remodeling, and identifiesFrontiers in immunology · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells in mammals perceive and react to the mechanical properties of their surrounding environment. Disease progression is frequently linked to dynamic changes in cellular and tissue mechanics. Mechanical responses have been investigated in a broad range of pathological states, notably viral and bacterial infections, inflammation, cystic fibrosis, and tumorigenesis. The lung is an inherently mechanosensitive organ. As such, it is subjected to tremendous mechanical forces. Evidence suggests that lung tumors are subjected to and react to active and passive forces that are critical for their initiation, differentiation, migration, and effector functions, as well as those of their extracellular matrix. This review discusses the latest advances in the investigation of the mechanics of lung cancer cells, focusing on the effects of mechanical signals from tumor microenvironment on tumor cell metabolism and tumor aggressiveness. Investigating the biological impacts of stress and stiffness alterations in lung cancer cells and their associated extracellular matrix can enhance our understanding the pathogenesis of lung cancer and offer novel insights for future therapeutic strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.