ArticleWomen's health reports (New Rochelle, N.Y.)2025
Gender Differences in the Associations Between Serum Urate and Cardiometabolic Risk Factors in Age-Matched Middle-Aged Japanese.
Article in Women's health reports (New Rochelle, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The purpose of this study was to determine whether gender affects associations between serum urate and cardiometabolic risk factors in age-matched men and women. Methods: The subjects were 4612 men and 4612 age-matched women (35-60 years old) who had undergone health-checkup examinations. The relationships between high urate (defined as the highest quartile for serum urate) and cardiovascular risk factors were compared between men and women using logistic regression analysis and receiver operating characteristic analysis. Results: The odds ratio (OR) of subjects with high urate versus subjects without high urate for metabolic syndrome was significantly higher in women than in men (women: 3.82 [95% confidence interval: 2.93-4.97] vs. men: 1.99 [1.63-2.42], Conclusions: The associations between hyperuricemia and cardiometabolic risk factors were age-independently stronger in women than in men. The results suggested that the cutoff values for hyperuricemia that are currently used should be redefined from the viewpoint of prevention of cardiovascular disease.
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