Evidence map›Paper›PMID 41133139›Full record

ReviewFrontiers in medicine2025

Incremental peritoneal dialysis: less is more-for the patient and the planet.

Luca Nardelli, Antonio Scalamogna, Carlo Alfieri, Federico Alberici, Giuseppe Castellano

Abstract readReview
In one paragraph

Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luca NardelliFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Antonio ScalamognaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Carlo AlfieriFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Federico AlbericiAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Italy.
Giuseppe CastellanoFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Climate change poses growing threat to global health, and paradoxically, the health-care sector-including nephrology-is a significant contributor to greenhouse gas (GHG) emissions. Dialysis, in particular, is resource-intensive. Yet, dialysis remains life-saving for over 4 million people globally, a number projected to rise sharply. While peritoneal dialysis (PD) offers a home-based alternative to hemodialysis with potentially lower environmental costs, it still generates considerable carbon emissions and waste-especially from the production, packaging, and transport of dialysate solutions. A typical continuous ambulatory PD patient generates over 600 kg of waste per year, much of it non-biodegradable polyvinyl chloride. PD's carbon footprint ranges from 1.2 to 4.5 tons of CO₂-equivalent annually, primarily from packaging and transport. Incremental peritoneal dialysis (iPD)-an approach that starts therapy at a reduced dose based on residual kidney function (RKF)-offers a more sustainable model. Incremental PD reduces water usage, plastic waste, and carbon emissions by as much as 30-45% compared to full-dose PD. Clinically, iPD is associated with better quality of life, fewer infections, less glucose exposure, and potential preservation of RKF. Economically, it offers substantial cost savings, with estimates up to €8,700 saved annually per patient. Despite its benefits, barriers to iPD adoption include provider unfamiliarity, patient reluctance to intensify treatment, reimbursement limitations, and the need for close RKF monitoring and clinical assessment. Addressing these challenges through policy reform, education, and digital tools could enable broader implementation of iPD, aligning kidney care with environmental stewardship.

Indexed as

carbon footprintdialysis wasteenvironmentgreen nephrologyincremental peritoneal dialysisperitoneal dialysisplastic wastewater usage

Identifiers

PMID41133139
PMCPMC12540302

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.