ArticleCureus2025
Perioperative Anesthetic and Hormonal Considerations in a Patient With Anti-glutamic Acid Decarboxylase Encephalitis: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Glutamic acid decarboxylase (GAD) is vital for gamma-aminobutyric acid (GABA) synthesis. Auto-antibodies against GAD deplete GAD levels and subsequently GABA, resulting in a hyper-excitatory state. A 41-year-old woman with anti-GAD encephalitis underwent bilateral oophorectomy for endometriosis. Despite treatments, the patient experienced limited improvement. Suppression with Depo-Lupron and subsequent bilateral oophorectomy resulted in significant improvement. Post-oophorectomy, she experienced seizure-like episodes, suggesting medication's role in modulating neuroexcitability. The case underscores the interplay between anti-GAD antibodies and general anesthetics, highlighting the importance of understanding perioperative management of autoimmune encephalitis. Research is needed for an optimal approach to this patient population, emphasizing interdisciplinary collaboration.
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