ArticleTranslational lung cancer research2025
Molecular and clonal evolution of primary lesions
Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Correlation Between Molecular Genetic Analysis and Nuclear Pleomorphism in Long-Term Recurrent and Metastatic Chordoma.Cancers · 2026Article
- A Darwinian Perspective on Tumor Evolution.International journal of biological sciences · 2026Review
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Clonality is an intrinsic phenomenon of disease evolution, with specific clones conferring increased aggressiveness. We aimed to evaluated the different divergent and unique mutational patterns in brain metastases (BM). Methods: This retrospective cohort study included patients with epidermal growth factor receptor ( Results: Thirty patients were included (73% female). Central nervous system (CNS) involvement was noted in 90% of the patients at diagnosis, with a median of two BM. 46% exhibited Ex19del, while the remainder had an L858R mutation. The most frequently co-mutated gene in primary lesions was Conclusions: The molecular features of BM differ from those of the primary tumor. These results indicate that specific brain metastatic clones can also result in systemic progression.
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