ArticleFrontiers in plant science2025
Integrated transcriptomic and metabolomic analysis reveals developmental stage-specific molecular responses to phosphorus deficiency in soybean.
Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Integrated transcriptome and metabolome analyses uncover stage-specific dynamic regulatory networks during sesame floral development.Frontiers in plant science · 2026Article
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9 authors.
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Abstract
Background and knowledge gap: Phosphorus (P) deficiency is a major constraint to crop productivity worldwide, yet the molecular mechanisms behind stage-specific responses to severe P limitation during soybean development are not well understood. Although previous studies have looked at P stress responses, comprehensive multi-omics analyses across different developmental stages are missing, which limits our understanding of how P-efficient cultivars manage metabolic and transcriptional responses throughout their growth cycle. Objectives and methods: This study used an integrated transcriptomic and metabolomic approach to analyze stage-specific responses to severe phosphorus limitation (99.875% reduction) in the P-efficient soybean cultivar Heinong 551 across four developmental stages: trefoil, flowering, podding, and post-podding. Results: Metabolomic profiling identified 280 differentially expressed metabolites (DEMs) during trefoil and 851 during flowering, showing a threefold increase in metabolic disturbance during reproductive development. Transcriptomic analysis revealed 15,401 differentially expressed genes (DEGs) across stages, with 94% occurring in early phases (trefoil: 3,825; flowering: 10,660). Functional enrichment showed stage-specific responses, with the trefoil stage enriched in cell wall and membrane processes, and flowering enriched in photosynthesis, isoflavonoid biosynthesis, and cuticle development. Transcription factor analysis identified 87 differentially expressed transcription factors from 31 families, mainly Conclusion: Carbon metabolism exhibited compensatory mechanisms, including increased RubisCO and invertase activities, while nitrogen metabolism involved the downregulation of nitrate reductase, glutamine synthetase, and protein content. These findings reveal stage-specific molecular strategies used by P-efficient soybeans under severe limitation and inform sustainable agriculture practices aimed at optimizing crop performance in phosphorus-deficient conditions.
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