Evidence map›Paper›PMID 41132858›Full record

ArticleActa pharmaceutica Sinica. B2025

Imaging poly(ADP-ribose) polymerase-1 (PARP1)

Xin Zhou, Jiahui Chen, Jimmy S Patel, Wenqing Ran, Yinlong Li, Richard S Van, Mostafa M H Ibrahim, Chunyu Zhao, Yabiao Gao, Jian Rong and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Discovery of novel radioligand [Acta pharmaceutica Sinica. B · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Synthesis of Novel SubstitutedACS medicinal chemistry letters · 2025
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Xin ZhouDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Jiahui ChenDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Jimmy S PatelDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Wenqing RanCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Yinlong LiDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Richard S VanDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
Mostafa M H IbrahimKresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Chunyu ZhaoDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Yabiao GaoDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Jian RongDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Ahmad F ChaudharyDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Guocong LiCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Junqi HuCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
April T DavenportDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
James B DaunaisDepartment of Internal Medicine, Section on Infectious Diseases, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Yihan ShaoDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
Chongzhao RanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MI 02114, USA.
Thomas L CollierDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Achi HaiderDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
David M SchusterDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Allan I LeveyDepartment of Neurology, Emory University, Atlanta, GA 30322, USA.
Lu WangCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine & Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Gabriel CorfasKresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Steven H LiangDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly(ADP-ribose) polymerase 1 (PARP1) is a multifunctional protein involved in diverse cellular functions, notably DNA damage repair. Pharmacological inhibition of PARP1 has therapeutic benefits for various pathologies. Despite the increased use of PARP inhibitors, challenges persist in achieving PARP1 selectivity and effective blood-brain barrier (BBB) penetration. The development of a PARP1-specific positron emission tomography (PET) radioligand is crucial for understanding disease biology and performing target occupancy studies, which may aid in the development of PARP1-specific inhibitors. In this study, we leverage the recently identified PARP1 inhibitor, AZD9574, to introduce the design and development of its

Indexed as

Cell deathDNA damageFluorine 18ImagingPARP1PETPoly(ADP-ribose) polymerase-1Positron emission tomography

Identifiers

PMID41132858
PMCPMC12541583

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.