ArticleNeurophotonics2025
Real-time single-vessel analysis reveals vascular-type-dependent blood-brain barrier dysfunction in rodent models of status epilepticus and neuroinflammation.
Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Significance: Recent evidence highlights significant heterogeneity of the blood-brain barrier (BBB) across vascular types, which becomes more pronounced under disease conditions. However, functional changes in vascular-type-dependent BBB leakage remain poorly characterized. Aim: We aimed to establish an analysis framework for quantifying single-vessel BBB total leakage and identifying vascular-type-dependent patterns of total leakage change in disease states. Approach: We introduce a method that combines Results: Real-time imaging clearly showed arterial BBB leakage in SE, whereas leakage in NI was likely venous. Conventional intensity-based metrics, including area under the curve (AUC), intensity fold change ( Conclusions: This integrated approach enables quantitative evaluation of vascular-type-dependent BBB total leakage and provides a platform for future studies on vessel-specific BBB alterations in neurological disorders.
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