Evidence map›Paper›PMID 41132803›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Altered adult brain morphology in a mouse model of late-onset fetal growth restriction.

Ruiyan Tan, Lindsay S Cahill, Shoshana Spring, Anastasia Smolina, Anum Rahman, Darren Fernandes, Mike Seed, Christopher K Macgowan, John C Kingdom, John G Sled

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruiyan TanDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-7195-4368
Lindsay S CahillDepartment of Chemistry, Memorial University of Newfoundland, St. John's, NL, Canada.
Shoshana SpringMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Anastasia SmolinaDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Anum RahmanDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Darren FernandesMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Mike SeedTranslational Medicine, SickKids Research Institute, Toronto, ON, Canada.
Christopher K MacgowanDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
John C KingdomDepartment of Obstetrics & Gynecology, University of Toronto, Toronto, ON, Canada.
John G SledDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late-onset fetal growth restriction (FGR) from placental insufficiency results in progressive fetal hypoxia and is often associated with poor neurodevelopmental outcomes. In response to hypoxia, fetal brain sparing physiology is activated to protect the developing brain from injury via enhancing oxygen delivery. However, this protection may not be robust, and some brain regions remain susceptible to hypoxic injury. In addition, not all injury is manifested during fetal life, and may present in infant development. Using a mouse model of late-onset FGR where gestation is extended for 24 h, equivalent to approximately 2 weeks in humans, we deployed longitudinal

Indexed as

developmental origins of health and diseaselate-onset fetal growth restrictionlongitudinal imagingmouse modelMRIpostnatal brain development

Identifiers

PMID41132803
PMCPMC12541470

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.