ArticleFrontiers in pediatrics2025
Arterialized oxygen tension and unfavorable clinical outcomes in pediatric cystic fibrosis.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Maintaining good lung function is a primary goal in managing Cystic Fibrosis (CF). As spirometry lacks sensitivity for detecting mild lung disease, early progression often remains unrecognized. To overcome this limitation, more sensitive monitoring tools are needed. We evaluated arterialized oxygen tension (pO Methods: In this retrospective observational single-center cohort study, arterialized gas exchange was assessed in 103 young people with CF (47 females, 56 males, aged 5-18 years). Trends from baseline (age 5 years) to early adulthood and performance relative to annual best pulmonary function (FEV1) and lung clearance index were examined, along with baseline oxygen tension's predictive value on future FEV1 decline and the occurrence of CF-related complications. Results: pO Conclusions: Early abnormal pO
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