ArticleFrontiers in oncology2025
To treat or not to treat? Adjuvant chemotherapy in 46 patients with stage IB lung squamous cell carcinoma: a real-world matched analysis.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The value of adjuvant platinum-based chemotherapy (ACT) in stage IB squamous cell carcinoma (SqCC) remains controversial. Methods: This retrospective study enrolled patients with surgically resected stage IB SqCC between January 2013 and August 2024. Clinicopathological characteristics and survival data were collected. To mitigate the impact of observed confounders, propensity score matching (PSM) was performed using clinically relevant covariates, including age, sex, tumor diameter, poor differentiation, spread through air spaces, visceral pleural invasion, and lymphovascular invasion, resulting in 46 well-matched patient pairs. The primary endpoint was disease-free survival (DFS). The secondary endpoint was overall survival (OS). Results: A total of 181 patients were enrolled in the study. Among them, 50 patients (27.6%) received adjuvant chemotherapy (ACT), while 131 patients (72.4%) were assigned to the clinical observation (CO) group. The ACT group had more patients <65 years ( Conclusions: ACT may not confer significant survival benefits in resected stage IB SqCC, with comparable disease-free and overall survival outcomes observed between treatment and observation groups.
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