ArticleFrontiers in oncology2025
Multiparametric MRI-based radiomics and deep learning for differentiating uterine serous carcinoma from endometrioid carcinoma: a multicenter retrospective study.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Uterine serous carcinoma (USC) and endometrioid endometrial carcinoma (EEC) are distinct subtypes of endometrial cancer with markedly different prognoses and management strategies. Accurate preoperative differentiation between USC and EEC is of great significance for tailoring surgical planning and adjuvant therapy. Purpose: To develop and validate a multiparametric MRI-based radiomics and deep learning (DL) model for preoperative distinguishing USC from EEC. Methods: A total of 210 patients (68 USCs and 142 EECs) from four hospitals who underwent preoperative MRI were enrolled in this retrospective study. Features from radiomics and deep learning were extracted using T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast enhanced MRI (CE-MRI). The least absolute shrinkage and selection operator (LASSO) analysis was employed to identify the most valuable features. Clinical-radiological characteristics, radiomics and DL features were constructed using a support vector machine (SVM) algorithm. The models were evaluated using receiver operating characteristic (ROC) and decision curve analysis (DCA). Results: The all-combined model of clinical-radiological characteristics, radiomics and DL features showed better discrimination ability than either alone. The all-combined model demonstrated superior classification performance, achieving an AUC of 0.957 (95% CI: 0.904-1.000) on the internal-testing set and an AUC of 0.880 (95% CI: 0.800-0.961) on the external-testing set. The DLR model demonstrated superior predictive performance compared to the clinical-radiological model, although the differences were not statistically significant in both the internal-testing set (AUC = 0.908 vs. 0.861, Conclusion: The integrated model, combining multiparametric MRI-based radiomics, deep learning features, and clinical-radiological characteristics, may be utilized for the preoperative differentiation of USC from EEC.
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