Evidence map›Paper›PMID 41132682›Full record

ArticleFrontiers in immunology2025

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction.

Hicham Sid, Theresa von Heyl, Sabrina Schleibinger, Romina Klinger, Leah Heymelot Nabel, Hanna Vikkula, Rodrigo Guabiraba, Vanaique Guillory, Ryan Scicluna, Mohanned Naif Alhussien and 7 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hicham SidDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Theresa von HeylDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Sabrina SchleibingerDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Romina KlingerDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Leah Heymelot NabelDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Hanna VikkulaDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Rodrigo GuabirabaUMR ISP, INRAE, Université de Tours, Nouzilly, France.
Vanaique GuilloryUMR ISP, INRAE, Université de Tours, Nouzilly, France.
Ryan SciclunaDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Mohanned Naif AlhussienDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Brigitte BöhmDepartment of Pathology, Bavarian Animal Health Service, Poing, Germany.
Benjamin SchadeDepartment of Pathology, Bavarian Animal Health Service, Poing, Germany.
Daniel EllederInstitute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Samantha SivesDivision of Immunology, The Roslin Institute and Royal (Dick), School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
Lonneke VerveldeDivision of Immunology, The Roslin Institute and Royal (Dick), School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
Sascha TrappUMR ISP, INRAE, Université de Tours, Nouzilly, France.
Benjamin SchusserDepartment of Molecular Life Sciences, Reproductive Biotechnology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoic acid-inducible gene I (

Indexed as

Avian ProteinsChickensDEAD Box Protein 58Influenza in BirdsAnimalsUbiquitin-Protein LigasesVirus ReplicationAvian ProteinsDEAD Box Protein 58Ubiquitin-Protein Ligasesavian influenza virusduckRIG-IRNF135transgenic chicken

Identifiers

PMID41132682
PMCPMC12540166

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.