Evidence map›Paper›PMID 41132681›Full record

ArticleFrontiers in immunology2025

Pannexin-1 hemichannels promote experimental colitis inflammation in a CD4

Pooja Rani Mina, Bruna de Gois Macedo, Caio Loureiro Salgado, Chloe Liliana Leff, Daniel Bihnam, Henrique Borges da Silva

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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pooja Rani MinaDepartment of Immunology, Mayo Clinic, Phoenix, AZ, United States.
Bruna de Gois MacedoDepartment of Immunology, Mayo Clinic, Phoenix, AZ, United States.
Caio Loureiro SalgadoDepartment of Immunology, Mayo Clinic, Phoenix, AZ, United States.
Chloe Liliana LeffDepartment of Immunology, Mayo Clinic, Phoenix, AZ, United States.
Daniel BihnamDepartment of Immunology, Mayo Clinic, Phoenix, AZ, United States.
Henrique Borges da SilvaDepartment of Immunology, Mayo Clinic, Phoenix, AZ, United States.

Funding

Control of antiviral memory CD8+ T cell longevity by extracellular ATP sensingR01AI170649 · NIAID · MAYO CLINIC ARIZONA · PI Henrique Borges da Silva · 2022 to 2026
$2.4M
NIAID NIH HHS R01 AI170649
6 · The paper itself

Abstract

Background: The development of ulcerative colitis (UC) is associated with inflammatory responses driven by effector CD4 Main findings: Here, we found that Pannexin-1 (PANX1) hemichannels, which promote ATP export to the extracellular environment, are crucial for the development of colitis. We found that PANX1, which is upregulated in UC patients, is required for the induction of colitis in multiple experimental models. The role of PANX1 is effector T cell-specific and is correlated with the accumulation of TNF-α producing pathogenic Th2-like cells. Effector conversion of CD4 Conclusions: Together, our results suggest that PANX1 promotes colitis-associated pathogenic Th2-like responses and a possible link between these cells and colitis neutrophilia.

Indexed as

CD4-Positive T-LymphocytesColitis, UlcerativeConnexinsNerve Tissue ProteinsAnimalsDisease Models, AnimalGATA3 Transcription FactorHumansInflammationMiceMice, KnockoutNeutrophilsTumor Necrosis Factor-alphaConnexinsGata3 protein, mouseGATA3 Transcription FactorNerve Tissue ProteinsPANX1 protein, humanPanx1 protein, mouseTumor Necrosis Factor-alphaCD4+ T cellscolitisneutrophilspannexin 1 (Panx1)Th2 (type-2) immune responses

Identifiers

PMID41132681
PMCPMC12540062

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.