ArticleF1000Research2025
Physical exercises to prevent and rehabilitate hospital-associated disability in hospitalised older people: A protocol for a living systematic review with network meta-analysis.
Article in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: During hospitalisation, older adults are at risk of developing functional declineunrelated to the condition for which they were admitted. The loss of independence in at least one activity of daily living is referred to as hospital-associated disability (HAD). A loss of functional independence in hospitalised older people is associated with a greater risk of nursing home placement and increased caregiver burden after hospital dismissal. It is essential to raise awareness of the HAD problem among older patients and to implement adequate preventive and treatment measures. Objectives: To evaluate systematically the effectiveness of physical exercise to prevent and rehabilitate HAD in people aged 65 years and over who are hospitalised in an acute care setting. To assess factors (training intensity, volume, and frequency) that potentially influence the effectiveness of physical exercise on HAD in such patients through meta-regression. Methods: We will conduct a living systematic review of randomised controlled trials including a network meta-analysis. For the outcome HAD, various physical exercise modalities such as resistance training, aerobic exercises or cycling could be proposed. Unlike pair-wise meta-analyses, which allow only head-to-head comparisons, network meta-analysis enables us to compare all modalities simultaneously. Guidelines from the Cochrane Handbook for a systematic review of interventions will be followed. Discussion: A network meta-analysis offers several advantages which are relevant in the context of the present review question: i) it allows the integration of multiple comparisons within one analytical framework; ii) it enables to the evaluation of the comparative effectiveness of each exercise modality, thus allowing for a hierarchy of interventions; iii) it increased precision of the effect estimates compared to traditional meta-analyses. The latter advantage is crucial for outcomes like functional decline after a hospital stay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.