Evidence map›Paper›PMID 41132617›Full record

ArticleJournal of obesity2025

Macrosomia and Childhood Growth Trajectories From Birth to 10 Years of Age: Findings From the ROLO Longitudinal Birth Cohort Study.

Sophie Callanan, Kaat Philippe, Anna Delahunt, Linda M O'Keeffe, Kate N O'Neill, Cara A Yelverton, Catherine M Phillips, Patrick J Twomey, Ciara M McDonnell, Declan Cody and 1 more

Abstract read
In one paragraph

Article in Journal of obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sophie CallananUCD Perinatal Research Centre, School of Medicine, National Maternity Hospital, University College Dublin, Dublin 2, Dublin, Ireland.ORCID 0000-0002-1146-2951
Kaat PhilippeSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Dublin 4, Dublin, Ireland.ORCID 0000-0001-5195-0098
Anna DelahuntUCD Perinatal Research Centre, School of Medicine, National Maternity Hospital, University College Dublin, Dublin 2, Dublin, Ireland.
Linda M O'KeeffeSchool of Public Health, University College Cork, Cork, Ireland.
Kate N O'NeillSchool of Public Health, University College Cork, Cork, Ireland.ORCID 0000-0003-4843-4265
Cara A YelvertonUCD Perinatal Research Centre, School of Medicine, National Maternity Hospital, University College Dublin, Dublin 2, Dublin, Ireland.
Catherine M PhillipsSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Dublin 4, Dublin, Ireland.ORCID 0000-0003-4916-4463
Patrick J TwomeyDepartment of Clinical Chemistry, St. Vincent's University Hospital, Dublin, Ireland.
Ciara M McDonnellDepartment of Paediatric Endocrinology & Diabetes, Children's Health Ireland, Temple Street Hospital, Dublin, Ireland.
Declan CodyDepartment of Diabetes & Endocrinology, Children's Health Ireland, Crumlin, Dublin, Ireland.
Fionnuala M McAuliffeUCD Perinatal Research Centre, School of Medicine, National Maternity Hospital, University College Dublin, Dublin 2, Dublin, Ireland.ORCID 0000-0002-3477-6494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Objective: Macrosomia is associated with overweight and obesity across the life course. Most research to date has been based on cross-sectional analyses, and longitudinal investigations between macrosomia and developmental trajectories of growth throughout the first decade of life are lacking. This research aimed to examine associations between macrosomia and postnatal growth trajectories from birth to 10 years of age. Subjects: Children ( Methods: Birthweight was recorded at delivery and dichotomised using the cut-off criteria for macrosomia (birthweight ≥ 4 kg and < 4 kg). Child weight, length/height, body mass index (BMI) and waist circumference were measured at birth, 6 months, 2, 5 and 10 years of age. Postnatal growth trajectories were developed using these longitudinal measurements from birth up to 10 years of age. Linear spline multilevel models were used to examine associations between macrosomia and postnatal trajectories with adjustment for confounders (maternal ethnicity, socioeconomic status, maternal age at delivery, maternal smoking in pregnancy, paternal BMI, adherence to gestational weight gain guidelines in pregnancy, sex of the child, original study group allocation, adherence to a special diet in pregnancy, maternal physical activity levels, metabolic complications in pregnancy and breastfeeding). Results: In this cohort, 53.7% ( Conclusion: Macrosomia was associated with early, but not later, childhood growth trajectories. Associations were weak and varied according to definition and growth measurement. The lack of strong results indicates uncertain clinical relevance and warrant additional future research in a larger cohort.

Indexed as

Child DevelopmentFetal MacrosomiaAdultBirth CohortBirth WeightBody Mass IndexChildChild, PreschoolFemaleHumansInfantInfant, NewbornLongitudinal StudiesMalePediatric ObesityPregnancy

Identifiers

PMID41132617
PMCPMC12543617

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.