Evidence map›Paper›PMID 41132541›Full record

ReviewFrontiers in pharmacology2025

Research progress on DNA hydroxymethylation in atrial fibrillation: a review.

Shaowei Fan, Jingjing Shi

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shaowei FanLugouqiao Second Community Health Service Center, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, China.
Jingjing ShiDepartment of Cardiological Medicine, China Academy of Chinese Medical Sciences Guang'anmen Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic modifications play a critical role in the pathogenesis and progression of cardiovascular diseases. Among these, DNA hydroxymethylation has garnered increasing attention in the fields of oncology, hematology, and neurological disorders, serving as a key mechanism for untangling molecular pathways underlying disease etiology. Although emerging evidence has begun to illuminate the role of DNA hydroxymethylation in cardiovascular conditions such as coronary artery disease and atherosclerosis, its implications in atrial fibrillation remain underexplored. This review aims to summarize current understanding and discuss potential mechanisms through which DNA hydroxymethylation may contribute to the development and progression of atrial fibrillation.

Indexed as

5-hydroxymethylcytosineatrial fibrillationcalcium signalingDNA hydroxymethylationoxidative stress

Identifiers

PMID41132541
PMCPMC12540444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.