Evidence map›Paper›PMID 41132505›Full record

ReviewExtracellular vesicles and circulating nucleic acids2025

Exosome miRNA sorting controlled by RNA-binding protein-motif interactions.

Zixuan Huang, Xuan Zhao, Wenjing Wen, Ruolin Shi, Gaofeng Liang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Extracellular vesicles and circulating nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zixuan HuangHenan International Joint Laboratory of Small Nucleic Acid and Tumor Precision Theranostics, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, Henan, China.
Xuan ZhaoHenan International Joint Laboratory of Small Nucleic Acid and Tumor Precision Theranostics, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, Henan, China.
Wenjing WenHenan International Joint Laboratory of Small Nucleic Acid and Tumor Precision Theranostics, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, Henan, China.
Ruolin ShiHenan Academy of Science, Zhengzhou 450000, Henan, China.
Gaofeng LiangHenan International Joint Laboratory of Small Nucleic Acid and Tumor Precision Theranostics, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes, as key mediators of intercellular communication, have shown great potential in disease intervention and therapy in recent years. As natural nanocarriers, exosomes play a crucial role in transporting a wide array of cargo. Among these, miRNAs carried by exosomes are pivotal in gene regulation and the modulation of cellular signaling. Given that miRNAs are essential gene regulators, understanding how miRNAs are selectively loaded into exosomes is crucial for the development of novel diagnostic and therapeutic approaches. This review provides a detailed overview of the biogenesis and secretion mechanisms of exosomes, with a particular focus on the molecular mechanisms governing miRNA sorting into exosomes. Specifically, it highlights the miRNA motifs associated with exosomes enrichment (EXOmotifs), as well as those related to intracellular miRNA enrichment (CELLmotifs), along with RNA-binding proteins (RBPs) involved in sorting. We summarize the current progress in this field and discuss strategies for engineering Exosomes - such as gene editing, drug loading, and surface modification - to enhance their functionality and specificity. By exploring these mechanisms, this review offers a theoretical foundation for the application of engineered exosomes in disease treatment and outlines future research directions and potential applications.

Indexed as

CELLmotifsengineered extracellular vesiclesEXOmotifsExtracellular vesiclesmicroRNA sortingRNA-binding proteins

Identifiers

PMID41132505
PMCPMC12540272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.