Obesity-related microbial dysbiosis as a potential modulator of tumour progression.

Omar Mokhashi, Jaideep Chakladar, Wei Tse Li, Michael Karin, Matthew Uzelac, Weg M Ongkeko

Abstract read

In one paragraph

Article in Access microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Omar Mokhashi *Department of Otolaryngology-Head and Neck, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0009-0009-2172-6488

Jaideep ChakladarDepartment of Otolaryngology-Head and Neck, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0002-9932-5504

Wei Tse LiDepartment of Otolaryngology-Head and Neck, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0003-0997-2220

Michael KarinLaboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-2758-6473

Matthew UzelacDepartment of Otolaryngology-Head and Neck, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0003-4927-9666

Weg M OngkekoDepartment of Otolaryngology-Head and Neck, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0002-2790-2480

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although there is a well-established connection between the gut microbiome and obesity, the specific mechanisms by which microbes regulate cell signalling, inflammation and adipocyte growth to influence disease severity in obese patients remain largely unclear. Subsequently, while obesity itself is a well-established risk factor for various cancers, the exact mechanisms by which it drives disease progression are not yet definitively known. In this study, we explored the link between obesity-associated microbiome alterations and cancer progression by analysing microbial abundance in tissue samples from obese and cancer patients, and we identified specific microbes correlated with body mass index (BMI) that are associated with key cancer-related pathways. Notably, BMI-associated microbial species such as

Indexed as

cancerinflammasomeinflammationmicrobiomeobesity

Identifiers

PMID41132413

DOI10.1099/acmi.0.001055.v4

PMCPMC12540031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.