Evidence map›Paper›PMID 41132405›Full record

ArticleOxford medical case reports2025

Paraneoplastic minimal change disease in malignant thymoma: a rare association progressing to end-stage renal disease.

Vinson James, Yonique Petgrave

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Vinson JamesPediatric Nephrology, Lebonheur Children's Hospital, Memphis, TN 38103.ORCID https://orcid.org/0000-0003-2897-925X
Yonique PetgravePediatric Nephrology, UT Southwestern Medical Center, Dallas, TX 75390.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thymoma, commonly seen in middle-aged and elderly individuals, is associated with autoimmune disorders. While renal involvement is rare, its occurrence remains poorly characterized. Case Presentation: We report a 24-year-old female with a ten-year history of malignant thymoma who developed nephrotic syndrome. Renal biopsy revealed minimal change disease (MCD), a rare paraneoplastic manifestation of thymoma. Despite treatment with steroids and rituximab, her renal function deteriorated, leading to end-stage renal disease (ESRD). This case underscores the challenges of managing paraneoplastic glomerular disease and highlights the need for better understanding of such rare associations. Conclusion: Thymoma-related glomerular diseases, often linked to immune dysregulation, pose significant treatment challenges. Recognizing these associations may guide more effective management strategies, particularly for patients unresponsive to steroids.

Indexed as

anti-nephrin antibodiesmetastatic malignant thymic epithelial neoplasmminimal change nephrotic syndromepodocyte dustingrituximabsteroid resistance

Identifiers

PMID41132405
PMCPMC12542980

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.