ArticleOxford medical case reports2025
'Malignant granular cell tumor of the Appendiceal orifice: a rare case and review of literature'.
Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Granular cell tumors (GCTs) are rare, mostly benign soft-tissue neoplasms, with only 8% occurring in the gastrointestinal tract, making the colon an uncommon location. We present the case of a 37-year-old Hispanic woman who underwent a screening colonoscopy due to a family history of colon cancer. A submucosal nodule at the appendiceal orifice was resected, and a biopsy revealed a malignant GCT, confirmed by S100-positive staining. The patient underwent a right hemicolectomy, with the resection showing a 2 mm focus of granular cell tumor with clear margins. Histopathology confirmed malignancy, with additional findings of reactive hyperplasia of mucosa-associated lymphoid tissue and focal ileitis. Although rare in the colon, malignant GCTs carry a high risk of mortality and recurrence. Small lesions (< 1 cm) can be monitored, but larger or malignant ones require surgical resection. Our case emphasizes the importance of early detection and intervention to prevent severe outcomes in malignant GCTs.
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