ArticleAdvanced biomedical research2025
NTCP Modeling of Visual Processing Speed Impairment and Related Factors Following Radiotherapy in Patients with Brain Metastases.
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: There have been numerous reports of impairment in neurocognitive functions, including visual processing speed (VPS), among patients who have developed brain metastasis. Therefore, this study aims to develop a model that calculates the probability of normal tissue complication arising from VPS impairment after whole-brain radiotherapy. Materials and Methods: In this study, 18 patients were examined for VPS impairment at the 4-month follow-up. After the hippocampus delineation, dose-volume histograms (DVHs) were generated. Normal tissue complication probability (NTCP) models were calculated for VPS using the Lyman model and multivariable logistic regression analysis. Results: VPS was observed in 33.3% of patients. TD Conclusion: This study modeled the probability of VPS following irradiation of the hippocampus. The NTCP curve showed that by keeping a maximum dose of hippocampi less than 20 Gy, NTCP becomes <25%.
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