Evidence map›Paper›PMID 41132221›Full record

ArticleAdvanced biomedical research2025

Simvastatin Neuroprotective Properties against Methylphenidate-Induced Neurodegeneration: Histological and Behavioral Evidence.

Mohammad Javad Shahabi, Abbas Jafarian, A Wallace Hayes, Majid Motaghinejad

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Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Mohammad Javad ShahabiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Abbas JafarianDepartment of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
A Wallace HayesInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI USA.
Majid MotaghinejadChronic Respiratory Disease Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The present study investigated the neuroprotective effect of simvastatin (SIM) against behavioral changes and histological alterations in the hippocampus induced by methylphenidate (MPH). Materials and Methods: Male Wistar rats were divided into the following groups: control, normal saline (0.2 mL), MPH (10 mg/kg), and MPH (10 mg/kg) plus SIM (10, 20, or 40 mg/kg). Open Field Test (OFT) and Elevated Plus Maze (EPM) evaluated mood and motor activity. Hippocampus DG and CA1 histomorphological changes were also evaluated. Result: MPH caused anxiety, depression, and motor activity disorder in animals in OFT and EPM ( Conclusion: SIM conferred neuroprotective properties against MPH-induced behavioral and inhibited MPH-prompted hippocampal cell changes.

Indexed as

Methylphenidateneurodegenerationneuroprotectivesimvastatin

Identifiers

PMID41132221
PMCPMC12543251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.