ArticleAdvanced biomedical research2025
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Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Cataracts are a leading cause of visual impairment worldwide, necessitating effective non-surgical preventative strategies. This study is the first to evaluate the morphological and histopathological effects of Materials and Methods: Seventy-two male Sprague-Dawley rat pups were randomly assigned to six groups: control (C), vehicle control (VC), ZE control (ZC), selenite (S), selenite plus vehicle (SV), and selenite plus ZE (SE). Cataracts were induced by a single subcutaneous injection of sodium selenite (30 μmol/kg) on postnatal day 8. ZE (500 μL/kg, diluted 1:1 with olive oil) was administered orally twice weekly for 5 weeks. Cataract severity was graded weekly by using Hiraoka's scale (0-6) by a blinded ophthalmologist. Histopathological changes were qualitatively assessed via hematoxylin and eosin staining. Statistical analysis employed the Kruskal-Wallis test with Dunn's post-hoc test. Results: No cataracts developed in the control groups (mean grade: 0). The S and SV groups developed severe cataracts (mean grade: 5.14 ± 0.64). ZE treatment significantly reduced cataract severity in the SE group (mean grade: 2.07 ± 0.59; Conclusion: This study provides the first morphological and histological evidence that ZE can prevent or delay cataract formation by preserving lens structure and function in a selenite-induced rat model. ZE demonstrates promising potential as a natural therapeutic agent for cataract prevention.
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