ReviewFrontiers in psychiatry2025
Postpartum depression-associated localized neural dysfunction: a voxel-wise meta-analysis of amplitude and synchronization alterations in resting-state fMRI.
Review in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Neurobiological insights into perinatal depression: a multi-dimensional integration of brain structure, function, and metabolism.Frontiers in psychiatry · 2026Pooled it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Resting-state fMRI studies in postpartum depression (PPD) have reported voxel-wise alterations in measures of neural amplitude and synchronization, yet scarce meta-analysis has quantitatively synthesized these findings. We performed a coordinate-based meta-analysis to identify convergent amplitude and synchronization dysfunction in PPD. Methods: We conducted a comprehensive search for whole-brain voxel-wise resting-state fMRI studies comparing PPD patients with healthy postpartum controls that reported local amplitude or synchronization metrics. Peak coordinates were analyzed using the Anisotropic effect size-signed differential mapping to delineate whole-brain functional alterations. Results: Ten studies (288 PPD patients, 279 controls) contributed 62 peak foci. Our analysis revealed that PPD patients exhibited increased activity in the left fusiform gyrus (FFG.L), left middle occipital gyrus (MOG.L), while showing decreased activity in the left anterior cingulate gyrus (ACG.L), the right superior temporal gyrus (STG.R), the right insula (INS.R) and the right precentral gyrus (PreCG.R) compared to healthy subjects. Jackknife sensitivity analysis indicated minimal impact on the overall results when eliminating any single study. Meta-regression analysis revealed a correlation between MOG.L functional activity and Edinburgh postnatal depression scale scores. Conclusion: Abnormally elevated functional activity in the FFG.L, MOG.L, along with reduced activity in the ACG.L, STG.R, INS.R and PreCG.R, may serve as potential biomarkers for PPD. Additionally, abnormal functional activity in the visual cortex, and the prefrontal cortex-limbic system may be associated with PPD.
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