Evidence map›Paper›PMID 41132166›Full record

ArticleThe Lancet regional health. Western Pacific2025

Effect modification of long-term air pollution exposure on the association of physical activity with COPD hospitalization: a prospective cohort study of 0.5 million Chinese adults.

Xi Xia, Cong Liu, Yue Niu, Xia Meng, Neil Wright, Christiana Kartsonaki, Yiping Chen, Ling Yang, Huaidong Du, Canqing Yu and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Western Pacific, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Xi XiaDepartment of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Cong LiuSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
Yue NiuSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
Xia MengSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
Neil WrightClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Christiana KartsonakiClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Yiping ChenClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Ling YangClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Huaidong DuClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Canqing YuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Dianjianyi SunDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Jun LvDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Junshi ChenChina National Center for Food Safety Risk Assessment, Beijing, China.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Maxim BarnardClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Kai KangHenan Center for Disease Control and Prevention, Zhengzhou, China.
Shaowei WuDepartment of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Ka Hung ChanClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Kin Bong Hubert LamClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Haidong KanSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
Zhengming ChenClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
China Kadoorie Biobank Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Little is known about how long-term ambient air pollution exposure modifies the potential benefits of physical activity against chronic obstructive pulmonary disease (COPD). We aimed to examine the interaction between ambient air pollution and physical activity in relation to risk of COPD hospitalization. Methods: In a prospective cohort study of 467,944 adults recruited from 10 areas of China and without spirometry-defined airflow obstruction at baseline in 2004-2008, we examined the exposure-response relationships of total physical activity levels (metabolic-equivalent of task-hour/day; MET-h/d) with COPD hospitalization, stratified by long-term exposure to ambient PM Findings: In 467,944 adults (mean [SD] age = 51.8 [10.6] years; 280,590 females, 187,354 males), 14,688 incidents of COPD were recorded during 5.9 million person-years of follow-up. Physical activity was inversely associated with COPD in participants exposed to low air pollution but showed weak or no association in those exposed to high air pollution (all p-interaction < 0.001). Comparing participants at the highest (≥29.8 MET-h/d) versus lowest quartile (<10.7 MET-h/d) of physical activity, there were 18-23% statistically significant lower risks among those with low air pollution exposure, but marginally significant elevated risks among those with high air pollution exposure (for PM Interpretation: Long-term exposure to ambient air pollution is associated with attenuation of the potential benefits of physical activity against COPD in Chinese adults. Funding: Sino-British Fellowship Trust, National Key Research and Development Program of China, Kadoorie Charitable Foundation, Wellcome, Noncommunicable Chronic Diseases-National Science and Technology Major Project, National Natural Science Foundation of China, UK Medical Research Council, Cancer Research UK, British Heart Foundation.

Indexed as

Ambient air pollutionChinaChronic obstructive pulmonary diseaseCohort studyPhysical activity

Identifiers

PMID41132166
PMCPMC12541231

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.