Evidence map›Paper›PMID 41132151›Full record

ArticleeGastroenterology2025

Autophagy related 14 protects against liver injury by inhibiting multiple cell death pathways.

Hyeong-Geug Kim, Menghao Huang, Shen Wang, Yang Zhang, Kailing Li, Sheng Liu, Chuanpeng Dong, Xiuxiu Yang, Jung-Hyo Cho, Kushan Chowdhury and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eGastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hyeong-Geug Kim *Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Menghao Huang *Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Shen WangDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Yang ZhangDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kailing LiLuddy School of Informatics, Computing, and Engineering, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Sheng LiuMelvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Chuanpeng DongLuddy School of Informatics, Computing, and Engineering, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Xiuxiu YangDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jung-Hyo ChoDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kushan ChowdhuryDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Barry SteinElectron Microscopy Center, Indiana University, Bloomington, Indiana, USA.
Jun WanMelvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Xiaocheng Charlie DongDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0001-5452-6882

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injuryR01AA028506 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI X. Charlie Dong · 2022 to 2026
$2.2M
Epigenetic regulation in liver fibrosisR01DK121925 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE · 2020 to 2023
$1.8M
Role of ATG14 in the regulation of hepatic functionR01DK120689 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE · 2020 to 2023
$1.7M
Role of SIRT6 in the pancreatic beta cell agingR21AG072288 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE · 2022 to 2023
$436k
NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NIAAA NIH HHS R01 AA028506NIA NIH HHS R21 AG072288NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK120689NIDDK NIH HHS R01 DK121925
6 · The paper itself

Abstract

Background: Autophagy is critical for cellular homeostasis. Autophagy related 14 (ATG14) is a key regulator of autophagy initiation; however, its role in hepatocyte survival remains poorly understood. This study aimed to investigate the hepatocyte-specific function of ATG14 Methods: We generated Results: Conclusion: Our data suggest that ATG14 is required for maintaining hepatocyte identity, survival and function and that hepatic ATG14 deficiency may lead to hepatomegaly, tissue injury, inflammation and fibrosis.

Indexed as

Atg14 protein, mouseAutophagyCell DeathHepatocytesLiver Diseases

Identifiers

PMID41132151
PMCPMC12542747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.