Evidence map›Paper›PMID 41132128›Full record

ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2025

Systemic inflammatory biomarkers in relation to lung function and exercise-induced bronchoconstriction in adolescents.

Karin Ersson, Kjell Alving, Margareta Emtner, Christer Janson, Henrik Johansson, Andrei Malinovschi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Systemic inflammatory biomarkers in relation to lung function and exercise-induced bronchoconstriction in adolescents.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karin ErssonDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0003-3185-3316
Kjell AlvingDepartment of Women's and Children's Health, Paediatrics, Uppsala University, Uppsala, Sweden.
Margareta EmtnerDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Christer JansonDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Henrik JohanssonDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Andrei MalinovschiDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-4098-7765

Funding

Astma- och AllergiförbundetBror Hjerpstedts stiftelseEllen, Walter and Lennart Hesselman Foundation for Scientific ResearchGillbergska stiftelsenHjärt-LungfondenKnut och Alice Wallenbergs StiftelseSignhild Engqvists stiftelseUppsala Läns förening mot hjärt- och lungsjukdomarVetenskapsrådet
6 · The paper itself

Abstract

introductionThe forced oscillation technique (FOT) complements spirometry in assessing lung function, with higher sensitivity to small airway dysfunction. Systemic inflammation is thought to influence lung development and exercise-induced bronchoconstriction (EIB), but its relationship to circulating inflammatory proteins in adolescents is unclear.

objectiveTo investigate associations between systemic inflammatory biomarkers and baseline lung function and post-exercise airway responses in adolescents.

methodsIn 143 adolescents (13-15 years) from a population-based cohort, baseline spirometry, FOT, and baseline blood samples were obtained. Participants completed an exercise challenge to assess EIB via changes in forced expiratory volume in 1 s (FEV

resultsHigher plasma levels of C-C motif chemokine 19 (CCL19) were significantly associated with lower FEV

conclusionElevated CCL19 may reflect systemic inflammatory processes contributing to impaired lung function in early adolescence. The observed atopy-related interactions suggest the need to consider atopy in studies of systemic inflammation and airway physiology.

Indexed as

Asthma, Exercise-InducedBiomarkersBronchoconstrictionInflammationLungAdolescentExerciseExercise TestFemaleForced Expiratory VolumeHumansMaleRespiratory Function TestsSpirometryBiomarkersadolescentsepidemiologyexercise‐induced bronchoconstrictioninflammatory biomarkersproteomicspulmonary function testing

Identifiers

PMID41132128
PMCPMC12550650

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.