ArticleAnimal bioscience2026
Transcriptome analysis reveals the key long non-coding RNAs and genes related to cashmere shedding in goats.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The mechanisms of lncBMP4 mediating BMP4 promoter activity to regulate the proliferation of dermal papilla cells in Hu sheep.Animal bioscience · 2026Article
- N6-methyladenosine (m6A)-circHECA facilitates the differentiation of SHF stem cells into hair follicle lineage through miR-449a-5p/LEF1 mediated Wnt/β-catenin pathway in cashmere goats.Animal bioscience · 2026Article
- Transcriptomic Analysis Reveals AKT1 Upregulation in Inner Mongolian Cashmere Goats at 12 and 15 Months of Age.Veterinary sciences · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
objectiveThe cashmere goat is renowned for the exceptional quality of cashmere fibers. The shedding of cashmere is closely related to the production processes in cashmere goats, but its molecular regulatory mechanism is not fully understood.
methodsIn this study, we collected skin tissues from both already-shed cashmere goats (AS) and non-shed cashmere goats (NS). Morphological differences were observed, and the relative expression levels of indicator genes distinguishing anagen from telogen phases of hair follicles were assessed. Whole transcriptome sequencing was employed to investigate key regulatory factors including long non-coding RNAs (lncRNAs) and different expression genes (DEGs) and followed by preliminary validation, interaction network construction and functional verification.
resultsComparative histological analysis found that the density, depth, width, hair bulb width and activity of secondary hair follicles (SHFs) in AS individuals were significantly lower than those in NS individuals. Expression detection results of indicator genes distinguishing anagen from telogen indicated that the SHFs of NS individuals were predominantly in telogen phase, whereas those of AS individuals showed a greater tendency towards anagen phase. Transcriptome sequencing analysis identified 450 DEGs with 338 upregulated and 112 downregulated. as Additionally, 352 lncRNAs with different expression were detected, including 168 upregulated and 184 downregulated. Regulatory networks involving lncRNAs and their co-expressed DEGs were established. The lncRNA LOC108637151 and its co-expression gene, Selenoprotein P (SEPP1), were identified as key regulatory factors of cashmere shedding in goats, both exhibiting elevated expression levels in AS individuals. The overexpression of LOC108637151 in dermal papilla cells (DPCs) resulted in the increased expression of its target gene SEPP1 and promoted the proliferation of DPCs in cashmere goats.
conclusionThis study identified key lncRNAs and genes related to cashmere shedding in goats, as well as their regulatory relationships. The results provided a basis for revealing the potential molecular mechanisms underlying cashmere shedding in goats.
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