Evidence map›Paper›PMID 41132070›Full record

ArticleAnimal bioscience2026

Effects of AMPK/PGC-1α on gluconeogenesis in skeletal muscle of animals under overwintering starvation and its molecular mechanism: review.

Chaoyong Huang, Huiyu Cheng, Binhong Wen, Wei Li, Baohua Luo, Dubala Wu, Jingshun Wang, Sile Hu, Jianghong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chaoyong HuangCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Huiyu ChengCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Binhong WenCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Wei LiCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Baohua LuoHulunbuir Agricultural and Animal Husbandry Science Research Institute, Hulunbuir, China.
Dubala WuCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Jingshun WangHulunbuir Agricultural and Animal Husbandry Science Research Institute, Hulunbuir, China.
Sile HuCollege of Life Science and Food, Inner Mongolia Minzu University, Tongliao, China.
Jianghong WuCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.

Funding

Inner Mongolia Autonomous Region Beef Cattle Breeding Innovation and Efficient Breeding System Construction Project YZ2023010Inner Mongolia Autonomous Region Department of Education YLXKZX-NMD-009Inner Mongolia Autonomous Region's Key Technology Tackling Plan 2023YFDZ0027Inner Mongolia Autonomous Region's Key Technology Tackling Plan 2025KJHZ0001Inner Mongolia Autonomous Region's Key Technology Tackling Plan 2025YFDZ0135National Natural Science Foundation of China 32260812Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region 2023NJYT23015
6 · The paper itself

Abstract

During the wintering period characterized by feed scarcity, animals activate the sympathetic nervous system (SNS)-β-adrenergic receptor (βAR)-AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signaling pathway in their bodies. This activation increases the transcriptional activity of forkhead box O1 (FOXO1) transcription factor and pyruvate dehydrogenase kinase 4 (PDK4), leading to the upregulation of gluconeogenesis-limiting genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). Additionally, it enhances the functions of carnitine palmitoyltransferase 1 (CPT1), uncoupling protein 1 (UCP1), cluster of differentiation 36 (CD36), and fatty acid transport protein (FATP). This promotes promote intermuscular fat oxidation and the production of gluconeogenesis precursor glycerol, thereby enhancing animal skeletal muscle gluconeogenesis to maintain animal energy homeostasis and life activities under low temperature and starvation conditions. This article describes the effects of overwintering starvation stress on the AMPK/PGC-1α signaling pathway and its molecular mechanism in animal skeletal muscle gluconeogenesis. The aim to provide a theoretical basis for optimizing sustainable breeding strategies and improving animal production performance in alpine regions.

Indexed as

AMP-activated Protein KinaseForkhead Box O1Overwintering Starvation StressPeroxisome Proliferator-activated Receptor Gamma Coactivator 1-alphaPyruvate Dehydrogenase Kinase 4Skeletal Muscle Gluconeogenesis

Identifiers

PMID41132070
PMCPMC12963756

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.