ArticleAnimal bioscience2026
Differential expression of long non-coding RNA in the hypothalamus-pituitary-gonadal axis of Wanxi white geese during laying and broodiness periods.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Multi-omics reveals the pituitary-mediated neuroendocrine mechanisms during the transition from the onset-of-birth to the laying period in Wanxi white geese.Poultry science · 2026Article
- Expression and regulation of lncRNAs in the testes of Yili geese with high and low sperm motility.BMC genomics · 2026Article
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10 authors.
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Abstract
objectiveThis study explored the molecular mechanism of the hypothalamus-pituitary-gonadal (HPG) axis on the regulation of brooding behavior and laying performance of Wanxi white geese (WWG). The transcriptome of the hypothalamus, pituitary, and ovarian tissues of laying and brooding WWG was sequenced to identify genes and long noncoding RNAs (lncRNAs) that may be important in regulating the egg-laying performance and broodiness behavior of WWG.
methodsThis study sequenced the lncRNA on the hypothalamus, pituitary, and ovarian tissues of WWG white geese during laying and broodiness periods to determine the differentially expressed lncRNA (DElncRNA) in the hypothalamus-pituitary-ovary axis. lncRNA- microRNA (miRNA)-messenger RNA (mRNA) (ceRNA) regulatory network was constructed using selected differentially expressed genes (DEGs), differentially expressed microRNAs (DEMs), and DElncRNAs. Differentially expressed DEGs, DEMs, and DElncRNAs were further confirmed via real-time quantitative polymerase chain reaction. The dual luciferase reporter gene assay confirmed a targeting relationship between the MSTRG.1166. 1/miR-450-x/SOX8 axis.
resultsA total of 184 (brooding period hypothalamus vs laying period hypothalamus), 180 (brooding period pituitary vs laying period pituitary), and 880 (brooding period ovary vs laying period ovary) DElncRNAs were screened. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analysis showed that the DElncRNAs significantly enriched Steroid hormone biosynthesis, Neuroactive ligand-receptor interaction, Calcium signaling, and other pathways. The ceRNA regulatory network of laying performance and nesting behavior was constructed through the database. MSTRG.1166.1-miR-450-x-SOX8, MSTRG. 7163.5-miR-182-x-CSMD1, XR_007167835.1- miR-277-z-RAB3B, MSTRG. 7163.5-miR-151-y-PAQR9, MSTRG.4615.2-miR-96-x-DAPK1, XR_007164924.1-miR-144-y-TFPI, XR_007161186.1-miR-205-x-THRB, MSTRG.10196.1/XR_001206277.2-miR-339-x-TRAF4, and MSTRG.9442.1-miR-9-y-FBN3 may play an important role in the ovarian development of WWG. The dual luciferase reporter gene assay confirmed a targeting relationship between the MSTRG.1166.1/miR-450-x/SOX8 axis. The results of this study systematically expounded on how the HPG axis involves lncRNA, miRNA, and mRNA to post-transcriptionally regulate the broodiness behavior and laying performance of WWG.
conclusionThe results will improve knowledge of the complex interaction between lncRNA and genes controlling laying performance and broodiness behavior.
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