Evidence map›Paper›PMID 41132024›Full record

ArticleThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi2025

Downregulation of the Tumor Suppressor P53 Gene associated with the Progression of Clinical Staging and the Incidence of Distant Metastasis in Indonesian Colorectal Cancer.

Yudith Annisa Ayu Rezkitha, Amal Arifi Hidayat, Irine Normalina, Maria Inge Lusida, Takashi Matsumoto, Yoshio Yamaoka, Muhammad Miftahussurur

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Article in The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yudith Annisa Ayu RezkithaDoctoral Programs of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Amal Arifi HidayatHelicobacter pylori and Microbiota Study Group, Institute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.
Irine NormalinaHelicobacter pylori and Microbiota Study Group, Institute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.
Maria Inge LusidaInstitute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.
Takashi MatsumotoDepartment of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan.
Yoshio YamaokaDepartment of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan.ORCID 0000-0002-1222-5819
Muhammad MiftahussururHelicobacter pylori and Microbiota Study Group, Institute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.ORCID 0000-0003-1415-6033

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: A genome-wide study identified tumor suppressor P53 (TP53), BRAF, KRAS, COL-3A1, and SOCS-2 as key drivers of tumorigenesis in human colorectal cancers (CRC). We investigated the association between these molecules' expression levels and the progression of clinical stage as well as the occurrence of distant metastasis in CRC. Methods: We recruited adult patients who underwent colonoscopy and had a histologically confirmed diagnosis of CRC. Clinical staging was determined following extensive workups. Immunohistochemistry (IHC) was used to evaluate the expression level of TP53, KRAS, BRAF, COL-3A1 and SOCS-2 in tumor biopsies. Results: The study involved 63 CRC patients, with a distribution across different stages: 1 (1.6%) in stage I, 6 (9.5%) in stage II, 30 (47.6%) in stage III, and 26 (41.3%) in stage IV. The expression level of TP53 gene were inversely correlated with clinical stages ( Conclusions: TP53 is downregulated in advanced clinical stages and distant metastases, demonstrating its role in aggressive nature of CRC.

Indexed as

Colorectal NeoplasmsTumor Suppressor Protein p53AdultAgedColonoscopyDisease ProgressionDown-RegulationFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryIndonesiaMaleMiddle AgedNeoplasm MetastasisNeoplasm StagingBRAF protein, humanKRAS protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Suppressor of Cytokine Signaling ProteinsTP53 protein, humanTumor Suppressor Protein p53CancerCarcinogenesisColorectal neoplasmsTumor suppressor protein p53

Identifiers

PMID41132024
PMCPMC12580058

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.