Observational studyAnnals of medicine2025
Association between neutrophil-to-lymphocyte ratio and early renal function decline in patients with immunoglobulin a nephropathy.
Observational study in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- A Clinical Prediction Model for Bacterial Coinfection in Children with Respiratory Syncytial Virus Infection: A Development and Validation Study.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIgA nephropathy (IgAN) is a chronic immune-mediated progressive kidney disease. The Neutrophil-To-Lymphocyte Ratio (NLR) has emerged as a novel marker for systemic immune inflammation. This study aimed to explore the relationship between NLR and early renal function decline in patients with IgAN.
methodsA real-world cross-sectional observational study was conducted on a cohort of 1073 patients diagnosed with IgAN. Patients were stratified into high and low NLR groups based on a predefined cut-off value. We examined the association between NLR levels and reduced renal function across these groups, defined as an estimated glomerular filtration rate (eGFR) of 60 mL/min·1.73 m
resultsAmong the 1,073 patients evaluated, those with an eGFR ≤ 60 mL/min·1.73 m
conclusionsIgAN patients with higher NLR levels exhibited more severe clinical manifestations. A high NLR may be associated with an increased risk of eGFR ≤ 60 mL/min·1.73 m
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