Evidence map›Paper›PMID 41131896›Full record

ReviewAdvanced healthcare materials2025

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications.

Ellie Martin, Sean P Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D Howes

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Reality of Active Targeting in Nanomedicine: Promise Versus Performance.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ellie MartinCollege of Technology and Environment, School of Engineering and Design, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.ORCID 0000-0002-6457-8800
Sean P DoidgeCollege of Technology and Environment, School of Engineering and Design, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.ORCID 0009-0001-8935-1952
Eiman AleemCancer, Infection and Therapeutics Research Group, College of Health and Life Science, School of Applied and Health Sciences, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.ORCID 0000-0002-9215-8213
Suela KelliciCollege of Technology and Environment, School of Engineering and Design, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.ORCID 0000-0003-1387-2345
Steven DunnCollege of Technology and Environment, School of Engineering and Design, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.ORCID 0000-0003-3795-5559
Claire AtkinsonCancer, Infection and Therapeutics Research Group, College of Health and Life Science, School of Applied and Health Sciences, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.ORCID 0009-0000-5182-4606
Philip D HowesCollege of Technology and Environment, School of Engineering and Design, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.ORCID 0000-0002-1862-8395

Funding

Royal Society of Chemistry R23-8055161780
6 · The paper itself

Abstract

Bioconjugation is a pillar of modern medicine, enabling the likes of targeted therapeutics and sensitive diagnostics by exploiting synergies between biomolecules and functional materials. Conjugation techniques have expanded to match an evolving materials discovery landscape, fueling a new wave of bioconjugates. Despite the breadth of conjugate literature, most reviews describe common and relatively simple substrates such as metal nanoparticles or polymers. This review therefore centers around novel materials including biological (e.g., viral capsids, live cells), hybrid (e.g., gold-decorated nanoparticles, covalent-organic frameworks), and synthetic (e.g., piezoelectrics, upconverting nanoparticles) substrates. Applications in cancer and viral therapy, tissue engineering, optogenetics, antimicrobials, diagnostics, advanced imaging, and related topics are explored, revealing trends in conjugation approach. This review also compares characterization techniques used to confirm and optimize conjugation before offering perspectives on the future of the field. By shedding light on the latest materials, applications, and analytical methods, we hope to empower researchers to harness bioconjugation for transformative medical innovations.

Indexed as

Biocompatible MaterialsAnimalsHumansMetal NanoparticlesPolymersTissue EngineeringBiocompatible MaterialsPolymersbio‐bio conjugationbioconjugationdiagnosticsnanozymesnovel materialstargeted therapy

Identifiers

PMID41131896
PMCPMC12683229

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.