Evidence map›Paper›PMID 41131864›Full record

ArticleInternational journal of stem cells2025

Dual Specificity Phosphatase 27 Regulates Pluripotency and Meso-Endodermal Differentiation by Interacting with Transcription Factor CP2 Like-1 in Embryonic Stem Cells.

Sujin Song, Jinbeom Heo, Siwon Lee, Yun Ji Nam, YongHwan Kim, Hyein Ju, Hyungu Kwon, Hyun Jun Im, Seok Woo Ha, Hyun Ji Kim and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sujin SongDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0004-4568-0676
Jinbeom HeoBiomedical Business Unit, Pharmicell Co., Ltd., Seoul, Korea.ORCID https://orcid.org/0000-0001-5672-0195
Siwon LeeDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0001-9395-8984
Yun Ji NamDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-7224-2960
YongHwan KimDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-0621-5937
Hyein JuDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-0948-8551
Hyungu KwonDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-7460-0437
Hyun Jun ImDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0008-3125-4915
Seok Woo HaDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0007-5735-1548
Hyun Ji KimDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0003-1946-3689
Dabin LeeDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0001-0616-1943
Sang Jin ParkDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0009-0002-1894-9313
Sang Hoon SongDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4888-483X
Juhyun ParkDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5549-9756
Eui Man JeongJeju Research Institute of Pharmaceutical Sciences, College of Pharmacy, Jeju National University, Jeju, Korea.ORCID https://orcid.org/0000-0003-0692-2033
Kyunggon KimDepartment of Medical Informatics and Biostatistics, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-3072-5331
Dong-Myung ShinDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-0511-5750
Seungun LeeDepartment of Cell and Genetic Engineering, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-5041-5368

Funding

NCIRD CDC HHS U01 IP000035NCIRD CDC HHS U66 IP000113
6 · The paper itself

Abstract

Transcription factor CP2-like protein 1 (Tfcp2l1), a naïve pluripotency transcription factor, is expressed in both early embryonic and adult tissues, where it enforces pluripotency of embryonic stem cells (ESCs) and stemness features of cancer cells, respectively. However, the detailed molecular pathways by which Tfcp2l1 is regulated in early embryonic development and cancer cells remain unknown. Here, we identified the pseudophosphatase dual specificity phosphatase 27 (Dusp27), also known as serine/threonine/tyrosine-interacting like-2, as a novel Tfcp2l1-interacting protein through a sterile alpha motif-like domain in the C-terminus of Tfcp2l1 in murine ESCs. The interaction between Dusp27 and Tfcp2l1 was dependent on the cell cycle status and increased during mitosis. Expression of

Indexed as

Dusp27Embryonic stem cellsNaïve pluripotencyTfcp2l1

Identifiers

PMID41131864
PMCPMC12658156

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.