ArticleJournal of clinical laboratory analysis2025
Predictive Value of Laboratory Assays Toward Autoimmune Diseases.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
objectiveWith an increasing number of unmet medical needs for autoimmune diseases (AD) in the United States, it is important to assess the value of laboratory assays in diagnosis. Healthcare providers must understand general and specific laboratory results that can lead to an efficient diagnosis.
methodsA nonexperimental study using a retrospective design and data collected between 2018 and 2021 was completed to explore whether the presence of positive anti-ENA and anti-dsDNA antibodies in individuals with an autoimmune disorder (anti-ENA, N = 1495; anti-dsDNA, N = 1261) can be predicted by their demographics and selected general laboratory test results.
resultsFor predicting anti-ENA, multiple logistic regression analysis χ
conclusionIn diagnosing an AD, ANA, complement C3, globulin, MLR, and BUN are important factors in patients with a positive anti-ENA. In determining Systemic Lupus Erythematosus diagnosis, complement C3, complement C4, pH, urine protein, and NLR are important factors in patients with a positive anti-dsDNA.
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