Evidence map›Paper›PMID 41131828›Full record

ArticleBiophysical journal2025

Plasma membrane-endoplasmic reticulum coupling probed with genetically encoded voltage sensors.

Masoud Sepehri Rad, Meyer B Jackson

Abstract read
In one paragraph

Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Masoud Sepehri RadDepartment of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address: sepehrirad@wisc.edu.
Meyer B JacksonDepartment of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address: meyer.jackson@wisc.edu.

Funding

Fusion pores in endocrine and synaptic exocytosisR35NS127219 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI MEYER B. JACKSON · 2022 to 2026
$4.7M
NINDS NIH HHS R35 NS127219
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) forms an elaborate contiguous network extending through the cytoplasm of eukaryotic cells. The ER is surrounded by a membrane that separates its lumen from the cytoplasm. The ER membrane harbors channels and pumps capable of controlling ion flux and creating a voltage gradient. Because the ER membrane potential is difficult to study experimentally, little is known about how voltage influences its many vital functions. Here, we introduce optical probes of ER membrane potential derived from the hybrid voltage sensor (hVoS) family of genetically encoded voltage sensors. Probes were targeted to the ER using motifs from three ER proteins, Sec61β, cytochrome P450, and cytochrome b

Indexed as

Cell MembraneEndoplasmic ReticulumAnimalsHEK293 CellsHumansMembrane PotentialsSEC Translocation ChannelsSEC Translocation Channels

Identifiers

PMID41131828
PMCPMC12709432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.