Evidence map›Paper›PMID 41131799›Full record

ArticleAsia-Pacific journal of clinical oncology2026

Quality of Life Among Thai Patients With Advanced Cancer: Findings From the APPROACH Study.

Waranee Bunchuailua, Nattiya Kapol, Sineenart Krichanchai, Waranya Krongkaew, Ellie Bostwick Andres

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asia-Pacific journal of clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07698782 (Advanced Cancer Stage and Healthcare Coverage Predict Longitudinal Psychological Distress and Clinical Outcomes in Patients Undergoing Radiotherapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07698782 nacompletednot on this map

Advanced Cancer Stage and Healthcare Coverage Predict Longitudinal Psychological Distress and Clinical Outcomes in Patients Undergoing Radiotherapy

TypeinterventionalSponsorChulabhorn Cancer CenterRan2025 to 2026Enrolled374ConditionsPsychological Distress, Clinical Outcomes, Cancer Patients Undergoning RadiotherapyArmsSystematic monitoring
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Waranee BunchuailuaDepartment of Health Consumer Protection and Pharmacy Administration, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Nattiya KapolDepartment of Health Consumer Protection and Pharmacy Administration, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Sineenart KrichanchaiDepartment of Health Consumer Protection and Pharmacy Administration, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Waranya KrongkaewDepartment of Pharmacy, National Cancer Institute, Bangkok, Thailand.
Ellie Bostwick AndresLien Centre for Palliative Care, Duke-NUS Medical School, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo examine quality of life (QoL), including physical, social, functional, and emotional well-being, and depressive symptoms among Thai patients with advanced cancer and their association with demographics, self-blame, perceived stigma, and quality of care.

methodsWe screened 392 medical records for patients seeking care at the National Cancer Institute in Thailand to achieve the APPROACH study target of 200 patients with Stage IV cancer per site. We surveyed participants using the APPROACH questionnaire, which comprised validated instruments (FACT-G, CES-D) and items developed by study investigators. We used multivariable regression models to examine associations.

resultsParticipants rated QoL more favorably than other APPROACH participants in Asia, and consistent with levels found in Singapore and the United States. Likewise, perceived cancer-related stigma (3%) was uncommon. However, self-blame (67%) was prevalent, a quarter of participants (27%) reported symptoms suggestive of clinical depression, and many (62%) expressed interest in mental health services, though prior use was minimal (n = 3). When associations with QoL were considered, characterological self-blame was negatively associated with overall QoL (β = -7.09, p = 0.026), physical (-3.69, p < 0.001), and functional (-0.91, p = 0.009) well-being, while high quality of care ratings were associated with better overall QoL (5.56, p < 0.001), enhanced physical (1.95, p < 0.001), functional (1.66, p < 0.001), and emotional (1.59, p < 0.001) well-being, and fewer depressive symptoms (-2.59, p < 0.001).

conclusionDespite relatively high QoL ratings, the pervasiveness of self-blame and its association with reduced QoL, the large proportion at risk for clinical depression, and the strong interest in mental health services suggest that many Thai patients with late-stage cancer may not be receiving sufficient mental health support at the end of life. Efforts to integrate mental health care into oncology services and comprehensive palliative care should be considered.

Indexed as

NeoplasmsQuality of LifeAdultAgedAged, 80 and overDepressionFemaleHumansMaleMiddle AgedSoutheast Asian PeopleSurveys and QuestionnairesThailandcancerdepressionend of lifemental healthpalliative carequality of carequality of lifeself‐blameThailand

Identifiers

PMID41131799
PMCPMC13007757

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.